The setting is a house in Harlem, New York some time in the year 2000. The action takes place mostly in a room in the house.
After a divorce with her husband Meg and her daughter Sara move to Harlem, New York looking for a new start in life. The first night after moving into their new three story house, burglars broke in to steal the money which the previous owner has left in a room with a steel bolted door called the Panic Room. After noticing the intruders presence, Meg wakes Sara up and took her into the Panic Room, and locked the door. Being in the room without any knowledge of what the burglars want. Meg uses a microphone in the room to negotiate with the burglars. After their response that what they want is inside the Panic Room, Meg is scared that they are there kill them rather than their claimed purpose. Meg won?t let them in. Struggling to survive ,Meg had to anticipate the next move as well as keeping her daughter from dying due to a medical condition. The burglars try to scare them, smoking them
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